科研教学
科研与学术
发布日期:2020-08-19 点击次数: 作者:
一、前言
妇产科是医院重点发展学科之一,是安徽医科大学妇产科学硕士学位授予点,自科室成立至今,在科研学术方面取得了令人瞩目的成就,包括申请了六项课题,其中省级以上课题3项,其他课题3项;发表了26篇学术论文,其中SCI论文19篇,中文核心7篇;出版专著1部《妇产科学分册》(人民卫生出版社),并在2016至2019年,成功组织了多次学术会议《妇科新能源应用技巧学习班》
,参会人数累计多达2000人。

二、申请课题情况

1. 省级以上课题三项:

国家自然基金青年科学基金项目,81801511,雄激素受体共激活因子BAP18在睾丸间质细胞及精子发生中的作用,2019/01-2021/12,21万元,在研,主持人:孙士莹;

国家自然基金青年科学基金项目,81802586,自噬促进NLRC5介导的MHC Ⅰ抗原提呈在子宫内膜癌免疫逃逸中的作用,2019/01-2021/12,21万元,在研,主持人:詹磊;

安徽省科技攻关计划项目,5101ID04041,盆腔血管发生规律及其血管闭塞动物模型的3D影像变化在盆腔肿瘤手术中的应用研究,2015/01-2017/12,10万元,结题,主持人:卫兵

2. 其他课题三项:

中国博士后科学基金第59批面上项目,2016M592038,盆腔血管发生规律及其血管闭塞动物模型的3D影像变化在盆腔肿瘤手术中的应用研究,2016/01-2018/12,5万元,结题,主持人:王文艳;

安徽省高校优秀青年人才支持计划重点项目,gxyqZD2016060,胎儿盆腔血管树的Micro-CT三维图像研究,2016/01-2018/12,6万元,结题,主持人:王文艳;

安徽高校自然科学研究重大项目,KJ2017A197,子宫内膜异位中NLRC5 对炎症的作用及相关机制的研究,2017/01-2018/12,6万元,结题,主持,主持人:詹磊

三、发表论文情况

1. SCI论文:
(1)Wenyan Wang, et al. Stimulative role of ST6GALNAC1 in proliferation, migration and invasion of ovarian cancer stem cells via the Akt signaling pathway. Cancer?Cell Int, 2019,19:86. doi: 10.1186/s12935-019-0780-7.
(2)Wenyan Wang, et al. Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy. Drug Des Devel Ther, 2019, 13:2205-2213.
(3)Wenyan Wang, et al. HMGA2 gene silencing reduces epithelial-mesenchymal transition and lymph node metastasis in cervical cancer through inhibiting the ATR/Chk1 signaling pathway. American Journal of Translational Research, 2018. 10(10):3036-3052.
(4)Wenyan Wang, et al. PTP1B promotes the malignancy of ovarian cancer cells in a JNK dependent mechanism. Biochemical and Biophysical Research Communications, 2018. 503(2):903-909.
(5)Wenyan Wang, et al. Abdominal wall endometriosis occurring after cesarean section: an underestimated complication. Clin Exp Obstet Gynecol, 2016, 43(5): 678- 684.
(6)Lei Zhan, et al. NLRC5 and autophagy combined as possible predictors in patients with endometriosis. Fertil Steril, 2018,110 (5), 949-956.
(7)Lei Zhan, et al. Autophagy Therapeutics: Preclinical Basis and Initial Clinical Studies. Cancer Chemother Pharmacol, 2018, 82 (6), 923-934.
(8)Lei Zhan, et al. Long non-coding RNAs in ovarian cancer. J Exp Clin Cancer Res, 2018, 37 (1), 120.
(9)Lei Zhan, et al. Autophagy in endometriosis: Friend or foe? Biochem Biophys Res Commun, 2018 , 495 (1), 60-63.
(10)Lei Zhan, et al. The role of TRPV4 in fibrosis. Gene, 2018, 642, 1-8.
(11)Lei Zhan, et al. Autophagy as an emerging therapy target for ovarian carcinoma. Oncotarget, 2016, 7 (50), 83476-83487.
(12)Lei Zhan, et al. Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis. Biochimie, 2016, 123, 130-137.
(13)Lei Zhan, et al. E2F1: A Promising Regulator in Ovarian Carcinoma. Tumour Biol, 2016, 37 (3), 2823-2831.
(14)Shiying Sun, et al. Expression and potential role of SNF5 in endometrial carcinoma. BMC Womens Health, 2019, 19(1):16.
(15)Pin Hu, et al. Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical cancer by regulating miR-508-3p/RGS17 axis. Life Sci, 2019, 234:116789.
(16)Lisha Jiang, et al. The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice. Sci Rep, 2019, 9(1):14456.
(17)Guiju Zhou, et al. TGF-β1 alleviates HgCl2 induced apoptosis via P38 MAPK signaling pathway in human trophoblast cells. Toxicol In Vitro, 2019, 61:104626.
(18)Yijun Fan, et al. Psychometric validation of the Chinese version of the Illness Perception Questionnaire-Revised for women with stress urinary incontinence. J Obstet Gynaecol Res, 2017, 43(8):1305-1316.
(19)Yijun Fan, et al. Incontinence-specific quality of life measures used in trials of sling procedures for female stress urinary incontinence: a meta-analysis. Int Urol Nephrol, 2015, 47(8):1277-95.

2. 中文核心:
(1)方子昂,程靖,王文艳,张妤,范懿隽,詹磊,凌琳,许胜红,卫兵.新生化颗粒联合透明质酸钠对宫腔粘连患者的疗效及血清TIMP-1、PDGF、MMP-9的影响[J].中国妇产科临床杂志,2019,20(05):401-403.
(2)姚顺,詹磊,孙士莹,王文艳,卫兵.NLRC5抑制自噬促进子宫内膜癌细胞增殖的研究[J].安徽医科大学学报,2019,54(07):1022-1027.
(3)蒋莉莎,陆义红,水丽君,邓敏.微小RNA-375通过靶向PAX6对宫颈癌HeLa细胞顺铂敏感性的影响[J].临床肿瘤学杂志,2018,23(06):501-507.
(4)张丽丽,卫兵,宋恩学,张婉莹,詹磊.个体化治疗剖宫产术后子宫瘢痕妊娠的临床探讨[J].南京医科大学学报(自然科学版),2017,37(06):758-761.
(5)高兰翠,王妍,王惠,卫兵.剖宫产妇运用抗菌药物预防感染的临床研究[J].中华医院感染学杂志,2017,27(07):1616-1619.
(6)何闰华,王文艳,卫兵.定坤丹对子宫内膜异位症模型大鼠的作用[J].安徽医科大学学报,2015,50(11):1693-1695.
(7)任娟,卫兵,宋恩学,王文艳,张丽丽.生长激素受体在宫腔粘连患者子宫内膜组织中的表达及意义[J].安徽医科大学学报,2015,50(07):1004-1007.
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